Where did this science come from? NLM, NIH, CDC, FDA, OXFORD JOURNALS, PUBMED…WHERE YOUR DR GETS HIS INFORMATION. (Besides the sales reps selling the vaccines to him)

NLM.NCBI.NIH.GOV–  The United States National Library of Medicine (NLM), operated by the United States federal government, is the world’s largest medical library. The NLM is a division of the National Institutes of Health. Its collections include more than seven million books, journals, technical reports, manuscripts, microfilms, photographs, and images on medicine and related sciences including some of the world’s oldest and rarest works.​

FDA.GOV– The Food and Drug Administration (FDA or USFDA) is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

CDC.GOV Centers for Disease Control and Prevention (CDC) is a United States federal agency under the Department of Health and Human Services.  It works to protect public health and safety by providing information to enhance health decisions, and it promotes health through partnerships with state health departments and other organizations.

Most other links/full text links are to direct online science journals also included in the NLM above. Make an INFORMED decision.

Mayo Clinic Proc, Nov 2003

“Case.—A previously healthy 14-year-old boy presented with fever and intermittent (lasting a few minutes) chest pain. The symptoms developed 3 days after he had received a vaccination for tetanus (Tetavax, Aventis Pasteur SA, Lyon, France). His medical history was unremarkable except for a severe skin eruption that occurred after trimethoprim- sulfamethoxazole treatment when he was 8 yearsof age. He had no history of adverse reactions to tetanus or other vaccinations. One recent report described a case of myopericarditis after triple vaccination against diphtheria, tetanus, and poliovirus. The patient had symptoms similar to our patient’s, with slightly elevated cardiac enzymes and normal findings on echocardiography and coronary angiography. The vaccination was the suspected cause in view of the chronology of the symptoms. Performing a provocative test that would confirm the causal relationship between the vaccination and the cardiac anomalies would be unethical.”

“Hypersensitivity myocarditis should be considered when new ECG changes occur in association with acute-onset chest pain, mildly elevated cardiac enzyme levels, and eosinophilia due to drugs and vaccination.”

Mayo Clin Proc, November 2003, Vol 78

Acute Myopericarditis After Multiple Vaccinations in an Adolescent: Case Report and Review of the Literature

“Our case highlights the fact that pediatricians should be aware of the often-dramatic presentation of postvaccination myopericarditis and its usually benign clinical course. The diagnosis of myocarditis should be entertained when acute-onset chest pain is accompanied by ECG changes and elevated cardiac enzyme levels. In cases in which the above-described presentation is temporally related to routine immunizations, the immunizations should be considered as a possible underlying etiology. ”

“The vaccination that has received great attention recently is that for smallpox, particularly after reinstitution of the vaccination for military personnel in 2002 and the reports of >50 cases of probable myocarditis temporally related to it”



Results For strict autism, probandwise concordance for male twins was 0.58 for 40 monozygotic pairs (95% confidence interval [CI], 0.42-0.74) and 0.21 for 31 dizygotic pairs (95% CI, 0.09-0.43); for female twins, the concordance was 0.60 for 7 monozygotic pairs (95% CI, 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09-0.69). For ASD, the probandwise concordance for male twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65-0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16-0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 dizygotic pairs (95% CI, 0.11-0.60). A large proportion of the variance in liability can be explained by shared environmental factors (55%; 95% CI, 9%-81% for autism and 58%; 95% CI, 30%-80% for ASD) in addition to moderate genetic heritability (37%; 95% CI, 8%-84% for autism and 38%; 95% CI, 14%-67% for ASD).
Conclusion Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.


Mercury and autism: accelerating evidence?

Autism spectrum disorders (ASDs) also known as pervasive developmental disorders (PDD) are a behaviorally defined group of neurodevelopmental disorders that are usually diagnosed in early childhood. ASDs disproportionately affect male children. Mercury (Hg) a heavy metal, is widespread and persistent in the environment. Mercury is a ubiquitous source of danger in fish, drugs, fungicides/herbicides, dental fillings, thermometers, and many other products. Elevated Hg concentrations may remain in the brain from several years to decades following exposure. This is important because investigators have long recognized that Hg is a neurodevelopmental poison; it can cause problems in neuronal cell migration and division, and can ultimately cause cell degeneration and death. Case-reports of patients have described developmental regressions with ASD symptoms following fetal and/or early childhood Hg exposure, and epidemiological studies have linked exposure to Hg with an elevated risk of a patient being diagnosed with an ASD. Immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with ASDs were reported following Hg (mercury) intoxication with similarities extending to neuroanatomy, neurotransmitters, and biochemistry. The sexual dimorphism of ASDs may result from synergistic neurotoxicity caused by the interaction of testosterone and Hg; in contrast, estrogen is protective, mitigating the toxicity of Hg. Mercury exposure may significantly increase androgen levels, and as a result, patients diagnosed with an ASD may significantly benefit from anti-androgen therapy. Finally, the clinical geneticist has a wealth of biomarkers to evaluate and treat patients diagnosed with an ASD.


“Varicella vaccination is less effective than the natural immunity that existed in prevaccine communities. Universal varicella vaccination has not proven to be cost-effective as increased HZ morbidity has disproportionately offset cost savings associated with reductions in varicella disease. Universal varicella vaccination has failed to provide long-term protection from VZV disease.”             PMID: 20642419


“Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM (insulin depedent diabetes).”


“We initiated and funded a collaborative study with Tuomilehto on the effect of the Haemophilus influenzae type b vaccine on type 1 diabetes and found that the data support a causal relation (paper submitted for publication). Furthermore, the potential risk of the vaccine exceeds the potential benefit.”


” The studies aiming to prove the widespread belief that healthcare worker vaccination decreases patient morbidity and mortality are heavily flawed and the recommendations for vaccination biased. No reliable published evidence shows that healthcare workers’ vaccination has substantial benefit for their patients—not in reducing patient morbidity or mortality and not even in increasing patient vaccination rates. Conclusion. The arguments for uniform healthcare worker influenza vaccination are not supported by existing literature. The decision whether to get vaccinated should, except possibly in extreme situations, be that of the individual healthcare worker, without legal, institutional, or peer coercion.”


“A fatal case of a 3-month-old female infant, who died within 24 h of vaccination with hexavalent vaccine is presented. Clinical data, post-mortem findings (acute pulmonary oedema, acute pulmonary emphysema), quali-quantitative data collected from immunohistochemical staining (degranulating mast cells) and laboratory analysis with a high level of beta-tryptase in serum, 43.3 microg/l, allows us to conclude that acute respiratory failure likely due to post hexavalent immunization-related shock was the cause of death.”


“Despite wide use of the influenza vaccine, relatively little is known about its effect on the measurement of inflammatory markers. Because inflammatory markers such as C-reactive protein (CRP) are increasingly being used in conjunction with lipids for the clinical assessment of cardiovascular disease and in epidemiologic studies, we evaluated the effect of influenza vaccination on markers of inflammation and plasma lipid concentrations”
“Our findings show that the influenza vaccination causes transient changes in select markers of inflammation and lipids. Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination.”


Polysorbate 80- an ingredient in vaccines- linked to infertility

“Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles”


“Acquired autoimmunity syndromes occur after viral vaccinations. Molecular mimicry is involved in these phenomena as is the necessity for the presence of two chemically complimentary antigens and an immunologic adjuvant. The HLA pattern of the host is also an important factor. The example used to explain these phenomena is demyelinating disease that follows hepatitis B vaccination. The somatic antigen of the hepatitis B virus in the vaccine has chemical complimentarity with the Epstein-Barr virus antigen in the vaccine recipient. The Epstein-Barr virus shows molecular mimicry with human myelin. The immunologic adjuvant is either present in the vaccine or muramyl peptides in the individual who is vaccinated. Why more than one type of autoimmune disease occurs is explained by the fact that specific autoimmune T-cells have been shown to develop clones that attack multiple human tissues.” PMID: 17630224


“Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined.  Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.”


Shedding and immunocompromised children.
No matter what they say, those vaccine viruses shed. And youre sitting their saying please get vaccinated and shed to my immunocompromised child!  Shedding viruses cause disease too!

“Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied.”


“The FluMist influenza vaccine strains replicate in the nasopharynx and can be recovered and cultured from respiratory secretions of vaccinated individuals (shed).  The pattern and duration of shedding is important to understand because with prolonged shedding at high titer there is a theoretical risk of loss of attenuated phenotype, reassortment with wild-type influenza virus during influenza season, and transmission of vaccine virus to unvaccinated people, some of whom may be immuno-compromised and/or at risk for complications of live viral infections. “  “additional shedding samples collected every 7 days … though some individuals shed vaccine strain virus as late as day 28”



“The RotaTeq vaccine contains five live, attenuated strains derived through laboratory reassortment of human rotavirus strains with a bovine rotavirus strain. Three RotaTeq strains each contain a single human rotavirus gene segment and ten bovine rotavirus segments, and two strains contain two human strain segments and nine bovine strain segments. In the study, RotaTeq was detected in 16 stool samples. Ten of these contained between one and four individual vaccine component strains. Six samples were found to contain a vaccine-derived G1P[8] (vdG1P[8]) strain. vdG1P[8] is believed to be the product of a genetic reassortment event in which the G1 gene segment of strain WI79-9 is inserted into strain WI79-4, as evidenced by the association of G1-VP7 and P[8]-VP4 human rotavirus genes with the M2-VP3 and I2-VP6 of the bovine rotavirus. Donato et al. observed that approximately a fifth of the infants having diarrhea within 2 weeks of rotavirus vaccination were shedding vaccine strain components exclusive of any detectable enteric pathogen.”


FULL TEXT http://www.expert-reviews.com/doi/full/10.1586/erv.12.114

“Analysis of 36 individuals over age 60 years who were immunized with  Zostavax revealed varicella zoster virus DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects  and in saliva collected over 28 days in 21 (58%) of 36 subjects. Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in ALL instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks.”

“Zostavax contains live attenuated VZV, and the package insert warns newly vaccinated individuals to avoid contact for an unspecified time with newborn infants, immunosuppressed individuals, and pregnant women who have not had chicken pox or have not been immunized for chicken pox. Because VZV DNA is present in saliva of zoster patients for at least 2 weeks [5] and VZV in saliva can also be infectious [6], we examined the inoculation site and saliva of Zostavax-vaccinated subjects for the presence of VZV DNA for 4 weeks after immunization”

FULL TEXT   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096786/

“Vaccines are not subject to double blind clinical trials despite the evidence of vaccine-drug interactions and perhaps also of vaccine-vaccine interactions.”
“Where is the proof that vaccines are safe? The argument has never been that they are completely safe but that the consequences are less than having the disease. Now it is illustrated that the consequences of intensive vaccination schedules pose a greater risk than could ever have been imagined. This leads to the evolution of new viral strains, an unsurprising development when the environment to which it is exposed is being altered by new proteins, structural variants and ALTERED DNA.”


“According to Hippocratic tradition, the safety level of a preventive medicine must be very high, as it is aimed at protecting people against diseases that they may not contract. This paper points out that information on the safety of hepatitis B vaccine (HBV) is biased as compared to classical requirements of evidence-based medicine (EBM), as exemplified by a documented selectivity in the presentation or even publication of available clinical or epidemiological data. Then, a review is made of data suggesting that HBV is remarkable by the frequency, the severity and the variety of its complications, some of them probablyrelated to a mechanism of molecular mimicry leading to demyelinating diseases, and the others reproducing the spectrum of non-hepatic manifestations of natural hepatitis B. To be explained, this unusual spectrum of toxicity requires additional investigations based upon complete release of available data.”


Download Full Study Here 

• “Although there is no information regarding the duration of acceptable observation period, 1–3 months may not be long enough for the purpose, considering that it takes 2–6 months for adjuvant oils to induce lupus autoantibodies in mice [8,9,34] and that the oil-induced granulomatous inflammation can last for years.”

“An important factor to consider in vaccine-induced autoimmunity is the fact that vaccines contain a microbial component (or other type of antigens) and adjuvant [75]. Differentiating adverse reactions caused by these two factors is often difficult, or it can even be a result of the combination of both. Nevertheless, the microbial components are generally considered responsible for adverse reactions and minimum attention has been paid to the potential effects of the adjuvant component. Molecular mimicry of a microbial antigen in a vaccine and a host tissue self-antigen is often considered important [61]. Immune complexes also may be formed following vaccination [61,76], deposit in vascular endothelium and induce vasculitis. Induction of cytokines or shifting cytokine balance may also play an important role.”


“Aluminium is the most widely distributed metal in the environment and is extensively used in daily life that provides easy exposure to human beings. The exposure to this toxic metal occurs through air, food and water. However, there is no known physiological role for aluminium within the body and hence this metal may produce adverse physiological effects. Chronic exposure of animals to aluminium is associated with behavioural, neuropathological and neurochemical changes. Among them, deficits of learning and behavioural functions are most evident. Some epidemiological studies have shown poor performance in cognitive tests and a higher abundance of neurological symptoms for workers occupationally exposed to aluminium.”


“We find that ethylmercury not only inhibits mitochondrial respiration leading to a drop in the steady state membrane potential, but also concurrent with these phenomena increases the formation of superoxide, hydrogen peroxide, and Fenton/Haber-Weiss generated hydroxyl radical. These oxidants increase the levels of cellular aldehyde/ketones. Additionally, we find a five-fold increase in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA nicks and blunt-ended breaks. Highly damaged mitochondria are characterized by having very low membrane potentials, increased superoxide/hydrogen peroxide production, and extensively damaged mtDNA and proteins. These mitochondria appear to have undergone a permeability transition, an observation supported by the five-fold increase in Caspase-3 activity observed after Thimerosal treatment.”


“Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community”


Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.

“Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide. In an initial series of experiments, we examined the potential toxicity of aluminum hydroxide in male, outbred CD-1 mice injected subcutaneously in two equivalent-to-human doses. After sacrifice, spinal cord and motor cortex samples were examined by immunohistochemistry. Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer’s disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted.”


Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as “small adults” with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., “ASIA”), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in “ASIA” and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Aluminum adjuvants.
In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed.”


• Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study

“In this pilot study, infant macaques receiving the recommended pediatric vaccine regimen from the 1990’s displayed a different pattern of maturational changes in amygdala volume and differences in amygdala-binding of [11C]DPN following the MMR/DTaP/Hib vaccinations between T1 and T2 compared with non-exposed animals. There was also evidence of greater total brain volume in the exposed group prior to these vaccinations suggesting a possible effect of previous vaccinations to which these animals had been exposed. Because primate testing is an important aspect of pre-clinical vaccine safety assessment prior to approval for human use (Kennedy et al. 1997), the results of this pilot study warrant additional research into the potential impact of an interaction between the MMR and thimerosal-containing vaccines on brain structure and function.”


Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure- Entropy 2012, doi:10.3390/e14112227

“Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.”

Article belongs to the Special Issue Biosemiotic Entropy: Disorder, Disease, and Mortality

“These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood. “


“Hepatitis B vaccination does not “generally” increase the risk of CNS inflammatory demyelination in childhood. However, the Engerix B vaccine appears to increase this risk, particularly for confirmed multiple sclerosis, in the longer term.”


Vaccinations create more powerful and virulent strains of bacteria and viruses.  The reason for the current whooping cough outbreak. Read more here from the CDC

“Vaccination against 2 avian viruses, the Marek disease virus, and the infectious bursal disease virus, were associated with the emergence of more virulent strains (33). An important role of host immunity in selecting for virulence is also suggested by the co-evolution of the myxomatosis virus and rabbits (34). Furthermore, immune pressure was shown to select for more virulent Plasmodium chabaudi parasites in mice (35). Based on mathematical modeling, vaccines designed to reduce pathogen growth rate and/or toxicity may result in the evolution of pathogens with higher levels of virulence (36).”


“A majority of the ophthalmological complications seen following hepatitis B vaccination consist of vision loss, optic neuritis, papillary edema, uveitis, acute placoid pigment epitheliopathy and central vein occlusion. We present a 9-year-old girl who was referred to our hospital with decrease in vision and pain in the left eye a week after hepatitis B vaccination. A diagnosis of vaccine induced optic neuritis was made.”



​”Most high-risk medical conditions that were measured were more prevalent among vaccinated than among unvaccinated persons.”


“Furthermore, while India has been polio-free for a year, there has been a huge increase in non-polio acute flaccid paralysis (NPAFP). In 2011, there were an extra 47,500 new cases of NPAFP. Clinically indistinguishable from polio paralysis but twice as deadly, the incidence of NPAFP was directly proportional to doses of oral polio received. Though this data was collected within the polio surveillance system, it was not investigated.”


Acute Fulminant Myocarditis after Diphtheria, Polio, and Tetanus Vaccination

“We report an infant case of acute fulminant myocarditis which occurred after administration of a diphtheria, polio, and tetanus vaccination. Fever and dyspnea developed after the vaccination. Extracorporeal membrane oxygenation was used for intractable cardiogenic shock. The patient survived the extracorporeal support, but poor ventricular contractility recurred 2 months later and she died while waiting for heart transplantation. ” “Hypersensitivity myocarditis due to vaccination has been reported sporadically.1–4 Occurrence of early fever after vaccination, negative results of microbial culture and the absence of associated symptoms for diphtheria, polio, and tetanus favor the diagnosis of hypersensitivity myocarditis. However, there was no definite evidence to support a causal link between the administration of vaccines and myocarditis. Repeated antigen injection is a well-established provocation test to substantiate a causal relationship, however this in itself raises ethical dilemmas.”

(so keep doing it without knowing?)


Myocarditis after triple immunisation.

“We describe a 3 month old infant who developed myocarditis several hours after diphtheria, tetanus, and pertussis vaccination. The time of occurrence of symptoms, the clinical course, and the negative virological studies suggest a possible cardiogenic adverse reaction to the vaccine.
“Helle et al found electrocardiogram changes suggestive of myocarditis without evidence of cardiac disease in 3% of a study population consisting of new army recruits after vaccination against diphtheria and smallpox. In addition, several episodes of paroxysmal supraventricular tachycardia were observed within a few hours after diphtheria, tetanus, and pertussis immunisation in a 2 month old infant prone to paroxysmal supraventricular tachycardia.”
“We believe that the myocardial reaction described was associated with the diphtheria, tetanus, and pertussis vaccination. Of the three components of the vaccine, either the diphtheria or the pertussis component probably provoked the myocardial damage.”


Myocarditis after Smallpox Vaccination: A Case Report

“A 20-year-old airman (US Air Force) developed myocarditis 8 days after smallpox vaccination. He was treated with nonsteroidal  anti-inflammatory agents, and his symptoms promptly resolved. However, postvaccinial myocarditis can lead to serious complications and even death.”
“This patient clearly had myocarditis in temporal relation to primary smallpox vaccination. Viral and postviral myocarditis has been described in young servicemen, and therefore we tried aggressively to rule out nonvaccinial causes of the cardiac abnormalities in this patient, including common viral, autoimmune, bacterial, and toxicological etiologies. Several similar cases of postvaccinial myocarditis have recently been detected in US servicemen (J. Grabenstein, written communications, February and March 2003). Currently, the longterm prognosis of this condition is not known.”

“Clinicians providing care to patients who have chest complaints after smallpox vaccination should be aware of the existence of postvaccinial myocarditis, which seems to be more common than previously thought.”


“We report the first cases of tissue-proven eosinophilic myocarditis after single vaccine administration of conjugate meningococcal C and hepatitis B vaccine, respectively. The nature of histopathologic findings strongly supports hypersensitivity reaction….To enhance discussion of our cases, we performed a systematic review of the literature on postimmunization myocarditis or pericarditis, and identified 37 publications, reporting 269 cases during the search period (1966-2007). Time of onset of cardiac symptoms in all patients ranged from 1 to 30 days postimmunization.” 2008


A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders.

Impairments in social relatedness and communication, repetitive behaviors, and stereotypic abnormal movement patterns characterize autism spectrum disorders (ASDs). It is clear that while genetic factors are important to the pathogenesis of ASDs, mercury exposure can induce immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with ASDs. The Institutional Review Board of the Institute for Chronic Illnesses (Office for Human Research Protections, U.S. Department of Health and Human Services, IRB number IRB00005375) approved the present study. A case series of nine patients who presented to the Genetic Centers of America for a genetic/developmental evaluation are discussed. Eight of nine patients (one patient was found to have an ASD due to Rett’s syndrome) (a) had regressive ASDs; (b) had elevated levels of androgens; (c) excreted significant amounts of mercury post chelation challenge; (d) had biochemical evidence of decreased function in their glutathione pathways; (e) had no known significant mercury exposure except from Thimerosal-containing vaccines/Rho(D)-immune globulin preparations; and (f) had alternate causes for their regressive ASDs ruled out. There was a significant dose-response relationship between the severity of the regressive ASDs observed and the total mercury dose children received from Thimerosal-containing vaccines/Rho (D)-immune globulin preparations. Based upon differential diagnoses, 8 of 9 patients examined were exposed to significant mercury from Thimerosal-containing biologic/vaccine preparations during their fetal/infant developmental periods, and subsequently, between 12 and 24 mo of age, these previously normally developing children suffered mercury toxic encephalopathies that manifested with clinical symptoms consistent with regressive ASDs. Evidence for mercury intoxication should be considered in the differential diagnosis as contributing to some regressive ASDs.


Autism: a novel form of mercury poisoning

“Thimerosal, a preservative added to many vaccines, has become a major source of mercury in children who, within their first two years, may have received a quantity of mercury that exceeds safety guidelines. A review of medical literature and US government data suggests that: (i) many cases of idiopathic autism are induced by early mercury exposure from thimerosal; (ii) this type of autism represents an unrecognized mercurial syndrome; and (iii) genetic and non-genetic factors establish a predisposition whereby thimerosal’s adverse effects occur only in some children.”


Annual influenza vaccination affects the development of heterosubtypic immunity. 2012 May 27.

Annual vaccination of healthy children >6 months of age against seasonal influenza has been recommended by public health authorities of some countries. However, currently used seasonal vaccines provide only limited protection against (potentially) pandemic influenza viruses. Furthermore, we recently hypothesized that annual vaccination may hamper the development of cross-reactive immunity against influenza A viruses of novel subtypes, that would otherwise be induced by natural infection. Here we summarize our findings in animal models in which we demonstrated that vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity against highly pathogenic avian influenza A/H5N1 virus, otherwise induced by a prior infection with influenza A/H3N2 virus. The reduction of heterosubtypic immunity correlated with reduced virus-specific CD8+ T cell responses. An additional study was performed in humans, in which we collected peripheral blood mononuclear cells from annually vaccinated children with cystic fibrosis (CF) and age-matched unvaccinated healthy control children to study the virus-specific T cell response. An age-related increase of the virus-specific CD8+ T cell response was observed in unvaccinated children that was absent in vaccinated children with CF. These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes. PMID: 22643217


“Together with an inflammatory reaction, influenza A vaccine induced platelet activation and sympathovagal imbalance towards adrenergic predominance. Significant correlations were found between CRP levels and HRV parameters, suggesting a pathophysiological link between inflammation and cardiac autonomic regulation. The vaccine-related platelet activation and cardiac autonomic dysfunction may transiently increase the risk of cardiovascular events.”


“During 2009-2010 they found that the risk of narcolepsy among people aged 4-19 years old who had received pandemic influenza vaccine was nine times higher than that among those who had not been vaccinated.”


“In August 2010 concerns were raised in Finland and Sweden about a possible association between narcolepsy and Pandemrix.13 A subsequent cohort study in Finland reported a 13-fold increased risk of narcolepsy after vaccination in children and young people aged 4-19, most of whom had onset within three months after vaccination and almost all within six months”

“The increased risk of narcolepsy after vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine indicates a causal association, consistent with findings from Finland.”


Acetaminophen use after measles-mumps-rubella vaccination was SIGNIFICANTLY associated with autistic disorder when considering children 5 years of age or less, after limiting cases to children with regression in development and when considering only children who had post-vaccination sequelae adjusting for age, gender, mother’s ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.


“A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT (autism) or SLI (speech or language impairment ). A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted”


Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of
Children with Regressive Autism: a Report of Three Cases. J Am Phys
Surg, Vol 9 No 2, 2004.

In light of encephalopathy presenting as autistic regression (autistic encephalopathy, AE) closely following measles-mumps- rubella (MMR) vaccination, three children underwent cerebrospinal fluid(CSF) assessments including studies for measles virus(MV). All three children had concomitant onset of gastrointestinal (GI) symptoms and had already had MV genomic RNA detected in biopsies ofileal lymphoid nodular hyperplasia(LNH). Presence of MV Fusion(F) gene was examined by TaqMan real- time quantitative polymerase chain reaction (RT-PCR) in cases and control CSF samples. The latter were obtained from three non- autistic MMR-vaccinated children with indwelling shunts for hydrocephalus. None of the cases or controls had a history of measles exposure other than MMR vaccination. Serum and CSF samples were also evaluated for antibodies to MV and myelin basic protein(MBP). MV F gene was present in CSF from all three cases, but not in controls. Genome copy number ranged from 3.7×10 to 2.42×10 per ng of RNA total. Serum anti-MBP autoantibodies were detected in all children with AE. Anti-MBP and MV antibodies were detected in the CSF of two cases, while the third child had neither anti-MBP nor MV antibodies detected in his CSF. Findings are consistent with both an MV (measles virus) etiology for the AE (autistic encephalopathy) and active viral replication in these children. They further indicate the possibility of a virally driven cerebral immunopathology in some cases of regressive autism.

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Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma.

Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity.

Differing time schedules for childhood immunizations may explain the discrepant findings of an association with asthma reported in observational studies. This research was undertaken to determine whether timing of diphtheria, pertussis, tetanus (DPT) immunization has an effect on the development of childhood asthma by age 7 years.
Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months. The likelihood of asthma in children with delays in all 3 doses was 0.39 (95% CI, 0.18-0.86).
We found a negative association between delay in administration of the first dose of whole-cell DPT immunization in childhood and the development of asthma; the association was greater with delays in all of the first 3 doses. The mechanism for this phenomenon requires further research.


​”There is extensive bi-directional communication between the brain and the immune system in both health and disease. In recent years, the role of an altered immune system in the etiology of major psychiatric disorders has become more apparent. Studies have demonstrated that some patients with major psychiatric disorders exhibit characteristic signs of immune dysregulation and that this may be a common pathophysiological mechanism that underlies the development and progression of these disorders. Furthermore, many psychiatric disorders are also often accompanied by chronic medical conditions related to immune dysfunction such as autoimmune diseases, diabetes and atherosclerosis. One of the major psychiatric disorders that has been associated with an altered immune system is schizophrenia, with approximately one third of patients with this disorder showing immunological abnormalities such as an altered cytokine profile in serum and cerebrospinal fluid. An altered cytokine profile is also found in a proportion of patients with major depressive disorder and is thought to be potentially related to the pathophysiology of this disorder. Emerging evidence suggests that altered immune parameters may also be implicated in the neurobiological etiology of autism spectrum disorders. Further support for a role of immune dysregulation in the pathophysiology of these psychiatric disorders comes from studies showing the immunomodulating effects of antipsychotics and antidepressants, and the mood altering effects of anti-inflammatory therapies. This review will not attempt to discuss all of the psychiatric disorders that have been associated with an augmented immune system, but will instead focus on several key disorders where dysregulation of this system has been implicated in their pathophysiology including depression, schizophrenia and autism spectrum disorder.”


“Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines. While a little is known of disease aetiology both conditions are characterised by an aberrant immune response, have a number of prominent symptoms in common and are coincident in many individuals. Herein, we have described a case of vaccine-associated chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating aluminium overload. This is the first report linking the latter with either of these two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in this individual. This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.


“The US childhood immunization schedule requires

26 vaccine doses for infants aged less than 1 year,

THE MOST IN THE WORLD, yet 33 nations have better Infant

Mortality Rates (IMR). Using linear regression, the

immunization schedules of these 34 nations were examined

and a correlation coefficient of 0.70 (p < 0.0001) was found

between infant mortality rates and the number of vaccine

doses routinely given to infants. When nations were grouped

into five different vaccine dose ranges (12–14, 15–17, 18–20,

21–23, and 24–26), 98.3% of the total variance in IMR was

explained by the unweighted linear regression model.

These findings demonstrate a counter-intuitive relationship:
nations that require more vaccine doses tend
to have higher infant mortality rates.

Efforts to reduce the relatively high UNITED STATES INFANT

MORTALITY RATE have been elusive. Finding ways to lower

preterm birth rates should be a high priority. However,

preventing premature births is just a partial solution to reduce

infant deaths. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs, is essential.All nations—rich and poor, advanced and developing—have an obligation to determine whether their immunization schedules are achieving their desired goals.”


Full scientific study can be seen here with all models:

A 44-year old man was admitted to our hospital with edema in his face and legs and cervical lymphadenopathy which occurred 18 days after influenza vaccine (Agrippal®, Novartis). The laboratory showed: creatinine 44mg/l, urea 106mg/dl. In the urinalysis was evident: proteinuria 4g/24h and hyaline casts. Serological test (ANA, DNA, ANCAp, ANCAc, C3, C4, HBsAg, HCV and HIV)  were negative. Renal biopsy was performed. Light microscopy showed evidence of severe acute tubular injury (Figure 1 A) and a moderate, diffuse interstitial inflammatory infiltrate consisting of mononuclear cells and severe edema.

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Rhabdomyolysis secondary to influenza A H1N1 vaccine resulting in acute kidney injury.

This is a rare side effect of influenza A H1N1 vaccine. Physicians should advise patients to seek medical care when muscle symptoms are present and consider the possibility of rhabdomyolysis due to vaccination. Trials are required to better define the incidence of this important side effect.”


“Although seasonal and H1N1 vaccines are safe and effective (CONTRADICTION), they also have the potential to induce autoantibodies in selected AIRD patients AND HEALTHY ADULTS. Follow-up of such individuals is proposed and further research is needed.”


“The neurotoxic organomercurial thimerosal (THIM), used for decades as vaccine preservative, is a suspected factor in the pathogenesis of some neurodevelopmental disorders. Previously we showed that neonatal administration of THIM at doses equivalent to those used in infant vaccines or higher, causes lasting alterations in the brain opioid system in rats.

Here we investigated neonatal treatment with THIM (at doses 12, 240, 1440 and 3000 μg Hg/kg) on behaviors, which are characteristically altered in AUTISM, such as locomotor activity, anxiety, social interactions, spatial learning, and on the brain dopaminergic system in Wistar rats of both sexes. Adult male and female rats, which were exposed to the entire range of THIM doses during the early postnatal life, manifested impairments of locomotor activity and increased anxiety/neophobia in the open field test.”


​Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders.

There is extensive bi-directional communication between the brain and the immune system in both health and disease. In recent years, the role of an altered immune system in the etiology of major psychiatric disorders has become more apparent. Studies have demonstrated that some patients with major psychiatric disorders exhibit characteristic signs of immune dysregulation and that this may be a common pathophysiological mechanism that underlies the development and progression of these disorders. Furthermore, many psychiatric disorders are also often accompanied by chronic medical conditions related to immune dysfunction such as autoimmune diseases, diabetes and atherosclerosis. One of the major psychiatric disorders that has been associated with an altered immune system is schizophrenia, with approximately one third of patients with this disorder showing immunological abnormalities such as an altered cytokine profile in serum and cerebrospinal fluid. An altered cytokine profile is also found in a proportion of patients with major depressive disorder and is thought to be potentially related to the pathophysiology of this disorder. Emerging evidence suggests that altered immune parameters may also be implicated in the neurobiological etiology of autism spectrum disorders. Further support for a role of immune dysregulation in the pathophysiology of these psychiatric disorders comes from studies showing the immunomodulating effects of antipsychotics and antidepressants, and the mood altering effects of anti-inflammatory therapies. This review will not attempt to discuss all of the psychiatric disorders that have been associated with an augmented immune system, but will instead focus on several key disorders where dysregulation of this system has been implicated in their pathophysiology including depression, schizophrenia and autism spectrum disorder.


Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation

We propose that, the events occurring in the patient may be explained as result of complex interactions between the individual genetic background and environmental exposure to infectious agents that generated a pro-inflammatory status, where the vaccine was the trigger for the subsequent alterations in thyroid and bone marrow. These findings highlight the importance of immunogenetic factors involved in response to vaccination that is the central theme in the growing field of ‘vaccinomics’ 2011


An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine.

“The biological properties of poxvirus isolates from skin lesions on dairy cows and milkers during recent exanthem episodes in Cantagalo County, Rio de Janeiro State, Brazil, were more like vaccinia virus (VV) than cowpox virus. PCR amplification of the hemagglutinin (HA) gene substantiated the isolate classification as an Old World orthopoxvirus, and alignment of the HA sequences with those of other orthopoxviruses indicated that all the isolates represented a single strain of VV, which we have designated Cantagalo virus (CTGV). HA sequences of the Brazilian smallpox vaccine strain (VV-IOC), used over 20 years ago, and CTGV showed 98.2% identity; phylogeny inference of CTGV, VV-IOC, and 12 VV strains placed VV-IOC and CTGV together in a distinct clade. Viral DNA restriction patterns and protein profiles showed a few differences between VV-IOC and CTGV. Together, the data suggested that CTGV may have derived from VV-IOC by persisting in an indigenous animal(s), accumulating polymorphisms, and now emerging in cattle and milkers as CTGV. CTGV may represent the first case of long-term persistence of vaccinia in the New World.”


“Similarly, vaccination is depicted as playing an important role in CFS onset. Recently, a case report pointed toward a causal association between silicone breast linkage, hepatitis B virus vaccination, and CFS onset in a previous healthy woman. Such findings suggest that there is a likely deregulation of the immune system influenced by specific agents (infections, vaccination, and products, such as silicone). Evidence suggests that CFS is a complex disease in which several risk factors might interact to cause its full expression. Thus, although different alterations have been found in CFS patients, undoubtedly the main feature is central nervous system involvement with immunological alterations. Therefore, a new term neuro-psycho-immunology must be quoted. New studies based on this concept are needed in order to investigate syndromes, such as CFS, in which immunological alterations are thought to be associated with concomitant psychological and health disturbances.”


“Persistence of the Rubella vaccine virus was also demonstrated in granuloma lesions sampled 4 to 5 years earlier. The persistence of rubella virus vaccine strain in three out of three consecutive cutaneous granuloma patients with PID strongly suggests a causal association between RV and granuloma in this setting.” Jan 2014


The language in the National Childhood Vaccine Injury Act of 1986 which specifically refers to vaccines as “unavoidably unsafe”(check ‘comment k’ of the Vaccine Act of 1986) Which the U.S. Supreme Court then decided, 22 Feb 2011 (6-2), to interpret as meaning vaccine manufacturers have immunity from all civil liability, regardless of whether avoidably or unavoidably unsafe – Bruesewitz v. Wyeth LLC, No. 09-152

“The Committee has set forth Comment K in this bill because it intends that the principle in Comment K regarding ‘unavoidably unsafe’ products, I.e., those products which in the present state of human skill and knowledge cannot be made safe, apply to the vaccines covered in the bill and that such products not be the subject of liability in the tort system.”

Id. , at 25–26.


l“ i.e., those products which in the present state of human skill and knowledge cannot be made safe,”

now, take out the explanation of unavoidably unsafe and here is what you get

“The Committee has set forth Comment K in this bill because it intends that the principle in Comment K regarding ‘unavoidably unsafe’ products,… apply to the vaccines covered in the bill and that such products not be the subject of liability in the tort system.” Id. , at 25–26.


Simultaneous sudden infant death syndrome.

“The simultaneous sudden deaths of twins rarely occur and therefore it has received limited attention in the medical literature. When the deaths of the twins meet the defined criteria for sudden infant death syndrome (SIDS) independently and take place within the same 24 h range it can be called as simultaneous SIDS (SSIDS). The case(s): Twin girls (3.5-month-old) were found dead by their mother in their crib, both in supine position. The infants were identical twins and delivered at a hospital by cesarean section. Both infants were healthy and did not have any serious medical history. Two days prior to the incident, the twins had received the second dose of oral polio, DPT and the first dose of hepatitis B vaccines and they had fever on the first day of the vaccination and been given teaspoonful of acetaminophen. Death scene investigation, judicial investigation, parental assessment, macroscopic and microscopic autopsy findings and the toxicological analysis did not yield any specific cause of death. The case(s) were referred to a supreme board composed of multidisciplinary medical professionals at the Institute of Forensic Medicine, Ministry of Justice, in Istanbul. The Board decided that the available data was consistent with SIDS. These SIDS case(s) are presented because twin SIDS are rare and this is the first time that a simultaneous twin SIDS have been reported in Turkey. Simultaneous SIDS cases have many implications regarding definition, diagnosis and medico-legal approach.” 2007


“ Additionally, a baboon endogenous virus strain M7 was detected, likely due to the monkey cell line in which RotaTeq was produced from.”

“ The sample of RotaTeq vaccine tested positive for rotavirus A and baboon endogenous virus, as previously reported by Victoria and colleagues [17]. The origin of the baboon endogenous virus is assumed to be related to the African green monkey-derived Vero cell line used in its manufacture and cross-hybridization of its endogenous retroviruses to the baboon endogenous retrovirus probes [17].

Microarray analysis did not detect PCV from the RotaTeq vaccine, which confirmed the previous results from Victoria et al. that LLMDA detected PCV from Rotarix but did not detect PCV from the RotaTeq vaccine [17]. However, PCV2 in RotaTeq vaccine was detected by PCR assays. RotaTeq contained small PCV-1 and PCV-2 genome fragments but did not contain detectable larger portions of PCV genomes [30]. Studies have shown that the amount of PCV in RotaTeq was about 4000 times lower than the PCV in Rotarix, with the PCV in RotaTeq being barely detectable [25, 31, 32]. A case study by Ranucci et al. has reported that the concentration of PCV-2 DNA fragment in clinical consistency lots was in the range of below limit of detection to 6.4 × 103 copies/mL when measured by QPCR, and that PCV1 was below limit of detection (0.1–0.8 × 103 copies/mL) [30]. ” 2014


“We report the first cases of tissue-proven eosinophilic myocarditis aftersingle vaccine administration of conjugate meningococcal C and hepatitis B vaccine, respectively. The nature of histopathologic findings strongly supports hypersensitivity reaction ………To enhance discussion of our cases, we performed a systematic review of the literature on postimmunization myocarditis or pericarditis, and identified 37 publications, reporting 269 cases during the search period (1966-2007). Time of onset of cardiac symptoms in all patients ranged from 1 to 30 days postimmunization.”


Aluminum as an adjuvant in Crohn’s disease induction

    “Alum (AlK(SO4)2) is an adjuvant commonly utilized in vaccines, and is a ubiquitous element used extensively in contemporary life….Crohn’s disease is a chronic relapsing intestinal inflammation in genetically susceptible individuals and is caused by yet unidentified environmental factors. Aluminum is a potential factor for the induction of inflammation in CROHN’S DISEASE, and its immune activities share many characteristics with the immune pathology of CROHN’S DISEASE: many luminal bacterial or dietary compounds can be adsorbed to the metal surface and induce Th1 profile cytokines, shared cytokines/chemokines, co-stimulatory molecules, and intracellular pathways and stress-related molecular expression enhancement, affecting intestinal macrobiota, trans-mural granuloma formation, and colitis induction in an animal CROHN’S DISEASE model. The inflammasome plays a central role in Aluminum mode of action and in CROHN’S DISEASE pathophysiology. It is suggested that Aluminum adjuvant activity can fit between the aberrations of innate and adaptive immune responses occurring in CROHN’S DISEASE. The CROHN’S DISEASE mucosa is confronted with numerous inappropriate bacterial components adsorbed on the Aluminum compound surface, constituting a pro-inflammatory supra-adjuvant. Aluminum fits the diagnostic criteria of the newly described autoimmune/inflammatory syndrome induced by adjuvants.

 If a cause and effect relationship can be established, the consequences will greatly impact public health and CROHN’S DISEASE prevention and management. ” 2012


Stroke after varicella vaccination.

Two children presented with acute hemiparesis 5 days and 3 weeks following varicella vaccination. Both showed unilateral infarction of the basal ganglia and internal capsule, a distribution consistent with varicella angiopathy. Both children had small patent foramen ovale (PFO), and one child also had severe iron-deficiency anemia, which may have predisposed the patient to this adverse effect.


Elevated blood histamine caused by vaccinations and Vitamin C deficiency may mimic the shaken baby syndrome.

“The findings of subdural hematoma and retinal hemorrhages in infants, without any documented history of major trauma, do not alw…ays indicate child abuse. A combination of ascorbate depletion and the injection of foreign proteins can cause a very high blood histamine level, leading to capillary fragility and venular bleeding. This can be prevented by the administration of vitamin C.”


Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants.

“We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.” JULY 31 2013


“For intramuscular and subcutaneous vaccinations, injections of sterile normal saline may serve as placebos, but researchers frequently choose other comparative agents. A review of the most recently published trials involving vaccines for children found a variety of comparators that took the place of placebos in children. For example, a recent study of pneumococcal conjugate vaccine with nine serotypes (PCV-9) used as its comparator an active vaccine [9]. Specifically, the PCV-9 was reconstituted with the DTP-Hib vaccine. The comparator was vaccine-diluent mixed with the same DTP-Hib vaccine. In another study, a novel, bivalent, heat-killed, whole-cell oral cholera vaccine is compared to a similarly manufactured, heat-killed Escherichia coli K12 vaccine-a vaccine of no therapeutic benefit [10]. In a third, recent study of a pneumococcal conjugate vaccine with seven stereotypes paired serially with a 23-valent, pneumococcal polysaccharide vaccine, the investigators used as the comparator hepatitis A or B vaccines [11]. In a fourth study, the study vaccine consisted of a Pseudomonas aeruginosa flagellar protein combined with aluminum hydroxide and thimerosal [12]. The comparator consisted of just aluminum hydroxide combined with thimerosal.”


“The use of tumorigenic and tumor-derived cells is a major safety concern due to the potential presence of viruses such as retroviruses and oncogenic (CANCER) DNA viruses that could be associated with tumorigencity (formation of tumors), Therefore, detection of persistent, latent (quiet) DNA viruses, and endogenous RETROVIRUSES (ex. AIDS is a slow replicating retrovirus) in vaccine cell substrates is important for vaccine safety, particularly in the development of live viral vaccines, where there are no or minimal virus inactivation and removal steps during vaccine manufacturing.”


“ However, since vaccine preparation involves the use of materials of biological origin, vaccines are subject to contamination by micro-organisms. In fact, vaccine contamination has occurred; a historical example of vaccine contamination, for example, can be found in the early days of development of the smallpox vaccine. The introduction of new techniques of vaccine virus production on cell cultures has lead to safer vaccines, but has not completely removed the risk of virus contamination. There are several examples of vaccine contamination, for example, contamination of human vaccines against poliomyelitis by SV40 virus from the use of monkey primary renal cells. Several veterinary vaccines have been contaminated by pestiviruses from foetal calf serum.These incidents have lead industry to change certain practices and regulatory authorities to develop more stringent and detailed requirements. But the increasing number of target species for vaccines, the diversity of the origin of biological materials and the extremely high number of known and unknown viruses and their constant evolution represent a challenge to vaccine producers and regulatory authorities.”


“We examined live virus vaccines against measles, mumps, and rubella for the presence of pestivirus RNA or of pestiviruses by reverse transcription PCR. Pestivirus RNA was detected in two measles-mumps-rubella combined vaccines and in two monovalent vaccines against mumps and rubella. Nucleotide sequence analysis of the PCR products indicated that a modified live vaccine strain used for immunization of cattle against bovine viral diarrhea is not responsible for the contamination of the vaccines.” (something else inside them is…)


“The novel human retrovirus xenotropic murine leukemia virus-related virus (XMRV) is arguably the most controversial virus of this moment. After its original discovery in prostate cancer tissue from North American patients, it was subsequently detected in individuals with chronic fatigue syndrome from the same continent. However, most other research groups, mainly from Europe, reported negative results. The positive results could possibly be attributed to contamination with mouse products in a number of cases, as XMRV is nearly identical in nucleotide sequence to endogenous retroviruses in the mouse genome. But the detection of integrated XMRV proviruses in prostate cancer tissue proves it to be a genuine virus that replicates in human cells, leaving the question: how did XMRV enter the human population? We will discuss two possible routes: either via direct virus transmission from mouse to human, as repeatedly seen for, e.g., Hantaviruses, or via the use of mouse-related products by humans, including vaccines. We hypothesize that mouse cells or human cell lines used for vaccine production could have been contaminated with a replicating variant of the XMRV precursors encoded by the mouse genome.”


“This overview describes the problems and risks associated with viral contaminations in animal cell culture, describes the origins of these contaminations as well as the most important viruses associated with viral contaminations in cell culture.” (cell cultures used in vaccines)

“contaminations are a serious threat for animal cell cultures and may lead to false results in research, development, and virus screening, to viral contaminations in the biologicals derived from the contaminated cultures and finally to an infection of the treated patient.”


“Current U.S. requirements for testing cell substrates used in production of human biological products (*VACCINES*) for contamination with bovine and porcine viruses are U.S. Department of Agriculture (USDA) 9CFR tests for bovine serum or porcine trypsin. 9CFR requires testing of bovine serum for seven specific viruses in six families (immunofluorescence) and at least 2 additional families non-specifically (cytopathicity and hemadsorption). 9CFR testing of porcine trypsin is for porcine parvovirus. Recent contaminations suggest these tests may not be sufficient. Assay sensitivity was not the issue for these contaminations that were caused by viruses/virus families not represented in the 9CFR screen. A detailed literature search was undertaken to determine which viruses that infect cattle or swine or bovine or porcine cells in culture also have human host range [ability to infect humans or human cells in culture] and to predict their detection by the currently used 9CFR procedures. There are more viruses of potential risk to biological products manufactured using bovine or porcine raw materials than are likely to be detected by 9CFR testing procedures; even within families, not all members would necessarily be detected….Cell-culture derived vaccines for human use were developed in the 1950’s. Since fetal calf serum and bovine or porcine trypsin were used in cell culture, the 9CFR tests developed for veterinary use to screen for viruses that can infect cattle and swine were implemented by the authorities regulating human vaccines. However, many viruses not of significant concern to the cattle and swine industry are not addressed by the 9CFR testing. Today, over half a century after cell culture-derived vaccines were initially developed, the human biologics industry is still using the methods specified in the 9CFR regulations for testing FBS and porcine trypsin.” OCT 2011


“vaccines are not standard from one batch to the next. 3. Unless the vaccine is properly prepared and refrigerated, its potency and reactivity varies with shelf life. In fact, the whole question of vaccine detoxification has never been systematically investigated. Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high pitched crying, somnolence, seizures, a shock-like “hypotensive, hyporesponsive” state, and an encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is the critical variable for determining causation.”


{Remember SV 40 is found in cancer patients}
“Mycoplasmas in frozen bovine serum were effectively inactivated by gamma-irradiation at 25-40 kGy. The larger viruses tested, respiratory enteric orphan (REO) and Cache Valley virus (CVV), were inactivated completely, while the smaller virus, simian virus type 40, was not inactivated. Gamma-irradiation of bovine-sourced serum is therefore useful for mitigating the risk of introduction of mycoplasmas and many of the viral contaminants found in biologics unprocessed bulk (e.g., CVV, REO virus, epizootic hemorrhagic disease virus).This mitigation strategy is not useful for the smaller viruses (e.g., polyomaviruses, parvoviruses, picornaviruses, caliciviruses).” 2010


“All currently licensed yellow fever (YF) vaccines are propagated in chicken embryos. Recent studies of chick cell-derived measles and mumps vaccines show evidence of two types of retrovirus particles, the endogenous avian retrovirus (EAV) and the endogenous avian leukosis virus (ALV-E), which originate from the chicken embryonic fibroblast substrates. In this study, we investigated substrate-derived avian retrovirus contamination in YF vaccines currently produced by three manufacturers (YF-vax [Connaught Laboratories], Stamaril [Aventis], and YF-FIOCRUZ [FIOCRUZ-Bio-Manguinhos]). Testing for reverse transcriptase (RT) activity was not possible because of assay inhibition. However, Western blot analysis of virus pellets with anti-ALV RT antiserum detected three distinct RT proteins in all vaccines, indicating that more than one source is responsible for the RTs present in the vaccines.”


” In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.”


“We describe a form of the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep, linked to the repetitive inoculation of aluminum-containing adjuvants through vaccination. The syndrome shows an acute phase that affects less than 0.5% of animals in a given herd, it appears 2-6 days after an adjuvant-containing inoculation and it is characterized by an acute neurological episode with low response to external stimuli and acute meningoencephalitis, most animals apparently recovering afterward. The chronic phase is seen in a higher proportion of flocks, it can follow the acute phase, and it is triggered by external stimuli, mostly low temperatures. The chronic phase begins with an excitatory phase, followed by weakness, extreme cachexia, tetraplegia and death. Gross lesions are related to a cachectic process with muscular atrophy, and microscopic lesions are mostly linked to a neurodegenerative process in both dorsal and ventral column of the gray matter of the spinal cord. Experimental reproduction of ovine ASIA in a small group of repeatedly vaccinated animals was successful. Detection of Al(III) in tissues indicated the presence of aluminum in the nervous tissue of experimental animals. The present report is the first description of a new sheep syndrome (ovine ASIA syndrome) linked to multiple, repetitive vaccination and that can have devastating consequences as it happened after the compulsory vaccination against bluetongue in 2008. The ovine ASIA syndrome can be used as a model of other similar diseases affecting both human and animals. A major research effort is needed in order to understand its complex pathogenesis.” 2013


Our findings indicate that vaccinal immunity might facilitate an evolutional event through antigenic selection,

genetic mutation among virulent virus populations shed from vaccinated flocks,

or both.”


Nonfebrile seizures after mumps, measles, rubella, and varicella-zoster virus combination vaccination with detection of measles virus RNA in serum, throat, and urine.

“We report the case of a child presenting with nonfebrile seizures 6 and 13 days after the first vaccination with a measles, mumps, rubella, and varicella (MMRV) combination vaccine. Measles virus RNA was detected in the patient’s serum, throat, and urine. Genotyping revealed the Schwarz vaccine virus strain.

An 11-month-old boy was presented to the pediatric unit after experiencing three seizures in the morning of the same day. The seizures were initiated by a sharp outcry with symmetric tonic-clonic movement of the arms and legs. During the seizures, the child was not reacting to his mother and had cyanotic lips. Seizures stopped spontaneously, without the administration of anticonvulsants, after approximately 1 to 2 min. Immediately after the seizures, body temperature, as measured by the mother as well as by the emergency physician, was not elevated (37.3°C). Upon admission, the child was sleepy but conscious and without signs of meningitis. The child had a slight rash on his trunk and pale skin color; otherwise, the clinical examination was unremarkable.

There was no history of seizures before or any other known medical conditions. Six days before the seizure, the first vaccination with the regular measles, mumps, rubella, and varicella (MMRV) vaccine (Priorix-Tetra; GlaxoSmithKline) was performed. In the meantime, there were no signs of infection or fever.

Viral concentration was low in serum and urine but remarkably higher in the throat swab.”
“Even though live attenuated measles vaccines have been used for more than 40 years, data are scarce on the extent to which vaccine virus replicates in or is shed by vaccinees (5). Isolation of infectious vaccine virus from the blood and pharynx of vaccinated children by propagation on canine renal cell culture was successfully performed in early studies with the Edmonston strain (9), from experimentally vaccinated Cynomolgus monkeys after vaccination with the Schwarz vaccine strain (10), and in a study evaluating fever and rash appearing 3 to 9 days after measles vaccination (11).” 2013


“We describe a death in a 15-mo-old girl who developed a varicella-like rash 20 d after varicella vaccination that lasted for 2 mo despite
acyclovir treatment. The rash was confirmed to be due to vaccine-strain varicella-zoster virus (VZV). This is the first case of fatal varicella
due to vaccine-strain VZV reported from the United States. The patient developed severe respiratory complications that worsened with each new
crop of varicella lesions; vaccine-strain VZV was detected in the bronchial lavage specimen. Sepsis and multi-organ failure led to death.
The patient did not have a previously diagnosed primary immune deficiency, but her failure to thrive and repeated hospitalizations early in life
(starting at 5 mo) for presumed infections and respiratory compromise treated with corticosteroids were suggestive of a primary or acquired immune
deficiency. Providers should monitor for adverse reactions after varicella vaccination. If severe adverse events develop, acyclovir should be
administered as soon as possible. The possibility of acyclovir resistance and use of foscarnet should be considered if lesions do not improve
after 10 d of treatment (or if they become atypical [e.g., verrucous]).” 2014


“We report the occurrence of one fatal case of the encephalitis associated with measles-rubella (MR) vaccine during an immunization campaign in São Paulo, Brazil. A 31 year-old-man, previously in good health, was admitted at emergency room, with confusion, agitation, inability to stand and hold his head up. Ten days prior to admission, he was vaccinated with combined MR vaccine (Serum Institute of India) and three days later he developed ‘flu-like’ illness with fever, myalgia and headache. Results of clinical and laboratory exams were consistent with a pattern of viral encephalitis. During hospitalization, his condition deteriorated rapidly with tetraplegia and progression to coma. On the 3rd day of hospitalization he died. Histopathology confirmed encephalitis and immunohistochemistry was positive for RV on brain tissue. RV was also detected by qPCR and virus isolation in cerebrospinal fluid, brain and other clinical samples. The sequence obtained from the isolated virus was identical to that of the RA 27/3 vaccine strain.”  2013


“We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection.” APR 2014


“More than 8 years after varicella vaccination, a healthy 16 year-old boy presented with keratouveitis, severe inflammatory glaucoma in his left eye, and Hutchinson’s sign. He was treated with systemic acyclovir, topical steroids, cycloplegics, and glaucoma medications for a full recovery two months after presentation. It is unclear whether the source of herpes zoster which reactivated in this patient represents wild type virus or his previous vaccine strain. Herpes zoster ophthalmicus is very rare in the pediatric population after varicella vaccination but can cause severe inflammatory glaucoma that requires aggressive therapy.”


“A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy. This case demonstrates that a negative VZV direct immunofluorescence assay does not exclude an infection with the vaccine strain.” 2013


“A 23-year-old teacher presented to hospital with a mild case of varicella. VZV vaccine strain vOka that resembles Varilrix but not Varivax or Biken strains was isolated from the skin lesion of the patient and was identified by single nucleotide polymorphism (SNP) analysis. The teacher denied having varicella vaccine before. Retrospective analysis suggests the transmission came from a pupil who developed zoster 13 months after varicella vaccine Varilrix.”


“A 25-day-old infant developed varicella 22 days after her mother received varicella vaccine postpartum. Infection with vaccine-strain varicella-zoster virus was confirmed by genetic analysis. The mother had no postvaccination rash nor did other contacts have rash or recent vaccination.” 2012


“A 12-year-old boy developed a skin rash following administration of MMR varicella zoster virus vaccine [route, dosage and outcome not stated].

The boy’s medical history included DiGeorge syndrome and juvenile idiopathic arthritis, which was treated with etanercept. He inadvertently received the MMR varicella zoster virus vaccine during a well-child visit. Ten days later, he was hospitalised with a 2-day history of fever, conjunctivitis, rash and sore throat. His mother held further doses of etanercept. Upon admission, physical examination revealed a blanching morbilliform rash on his face, ears, neck, chest, back and limbs. He also had mild conjunctivitis, palatal petechiae with posterior pharyngeal erythema and mild post auricular cervical lymphadenopathy.

The boy began receiving aciclovir. Urine and skin samples were positive for measles virus, and were phylogenetically clustered as genotype A with Edmonston reference strain. He was diagnosed with vaccine-associated disease.” 2014

-Pediatric Infectious Disease Journal 33: 117, No. 1, Jan 2014 – USA

“An outbreak of nine cases of mumps was reported from a total of 97 vaccinated nursing students at two medical colleges in Thailand in 2010, 16-26 days after administration of MMR vaccine containing the L-Zagreb mumps strain……This study provides another virologically confirmed example of mumps resulting from the L-Zagreb vaccine strain.” 2013


“Healthcare workers born after 1980 were 20 times (95% CI: 11.0 to 37.2) more likely to be susceptible to measles, and 2 times (95% CI: 1.2 to 3.2) more likely to be susceptible to varicella than those those born before 1965.

CONCLUSIONS:The susceptibility to measles in healthcare workers in our centre is higher in younger cohorts, with values higher than expected in a community with high vaccination coverage against measles, mumps, rubella vaccine (MMR) in the paediatric population for many years.” 2012


“we describe a previously immunized child who developed herpes zoster with meningitis. Vaccine strain of VZV was recovered from a skin swab and the cerebrospinal fluid. Reactivation of the vaccine strain of VZV should be recognized as a potential cause of meningitis in children.” 2011


“This study does not prove a causal relationship between the hexavalent vaccination and SIDS. However, we hypothesize that vaccine components could *have a *direct *role in sparking off a *lethal outcome in vulnerable *babies*. In conclusion, we sustain the need that deaths occurring in a short space of time after hexavalent vaccination are appropriately investigated and submitted to a post-mortem examination particularly of the autonomic nervous system by an expert pathologist to objectively evaluate the possible *causative *role of the vaccine in SIDS.” 2014


“Zostavax contains live attenuated VZV, and the package insert warns newly vaccinated individuals to avoid contact for an unspecified time with newborn infants, immunosuppressed individuals, and pregnant women who have not had chicken pox or have not been immunized for chicken pox. Because VZV DNA is present in saliva of zoster patients for at least 2 weeks [5] and VZV in saliva can also be infectious [6]”


So taking Antibiotics in the months or year before vaccinations makes them ineffective and *HARMFUL*. Creating “SYSTEMIC” Inflammation also known as…. the birth of chronic illness and disease.

“Bifidobacterium predominance may enhance thymic development and responses to both oral and parenteral vaccines early in infancy, whereas deviation from this pattern, resulting in greater bacterial diversity, may cause*SYSTEMIC inflammation* (neutrophilia) and lower vaccine responses. Vaccine responsiveness may be improved by promoting intestinal bifidobacteria and minimizing dysbiosis early in infancy.” Aug 2014


Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB).


Data for the primary outcome (prevention of disease) were lacking. We performed a meta-analysis to pool the results of 20 studies with 5874 participants in an immunogenicity analysis and 5232 participants in the reactogenicity analysis. There were no data on clinical outcomes for the primary outcome (prevention of disease) and all studies used immunogenicity and reactogenicity (adverse events). The number of vaccine doses differed significantly between the studies. Heterogeneous interventions, study location, healthcare environment and combining research across disparate geographical locations, may have lead to bias. The risk of bias was unclear across most of the included studies. Comparisons found little heterogeneity. In two immunological responses the combined vaccine achieved lower responses than the separate vaccines.”

Cochrane Database Syst Rev. 2012 Apr


Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. {NOT BY WAKEFIELD 😉 }

“Considering an autoimmunity and autism connection, brain autoantibodies to myelin basic protein (anti-MBP) and neuron-axon filament protein (anti-NAFP) have been found in autistic children. In this current study, we examined associations between virus serology and autoantibody by simultaneous analysis of measles virus antibody (measles-IgG), human herpesvirus-6 antibody (HHV-6-IgG), anti-MBP, and anti-NAFP.

We found that measles-IgG and HHV-6-IgG titers were moderately higher in autistic children but they did not significantly differ from normal controls.

Moreover, we found that a vast majority of virus serology-positive autistic sera was also positive for brain autoantibody: (i) 90% of measles-IgG-positive autistic sera was also positive for anti-MBP; (ii) 73% of measles-IgG-positive autistic sera was also positive for anti-NAFP; (iii) 84% of HHV-6-IgG-positive autistic sera was also positive for anti-MBP; and (iv) 72% of HHV-6-IgG-positive autistic sera was also positive for anti-NAFP. This study is the first to report an association between virus serology and brain autoantibody in autism; it supports the hypothesis that a virus-induced autoimmune response may play a causal role in autism.”


Autism as Autoimmunity-

“Autistic children had significantly higher serum antinucleosome-specific antibodies than healthy children. The seropositivity of antinucleosome-specific antibodies was found in 46.7% of autistic children.

“There is a strong association between autism and the major histocompatibility complex for the null allele of C4B in the class III region. This results in low production of C4B protein, leading to repeated infections that play an important role in the development of autoimmunity [15-18]. Some autistic children have an imbalance of T helper (Th)1/Th2 subsets toward Th2, which are responsible for allergic response and production of autoantibodies.”

“Serum levels of antinucleosome-specific antibodies were increased in some autistic children. ….. The role of immunotherapy in children with autism should be also studied.”

This case-control study was conducted on 60 children who had classic-onset autism {Not Regressive Autism}, over a period of 6 months from the beginning of June 2013 to the end of November 2013.

“Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children.”


Note: .01% of aluminum is absorbed via the gastrointestinal tract. (Krewski et al 2007, Priest 2004) Injection of Aluminum adjuvants via vaccination? Absorbtion rate 100%

“Hepatitis B vaccine might be followed by various rheumatic conditions and might trigger the onset of underlying inflammatory or autoimmune rheumatic diseases.. Further epidemiological studies are needed to establish whether hepatitis B vaccination is associated or not with an incidence of rheumatic disorders higher than normal. A few cases of onset or reactivation of SLE after vaccination against hepatitis B have been described. The onset of symptoms occurred within 5 days–1 month after the immunization. Two patients had a lupus nephritis (associated in one with fever and arthralgia), one patient had pericarditis, one had thrombocytopenic purpura.. We observed four patients with myalgia and polyarthralgia, and, in three of them, fatigue following hepatitis B vaccination. These manifestations can be connected to the chronic fatigue syndrome. A few years ago, an independent working group agreed that there was no evidence of a cause–effect relationship between hepatitis B vaccine and chronic fatigue syndrome [37]. However, the number of patients followed up may have been too small to detect a slight increase in the relative risk.”


“In summary, the present study documents that exposure of infant rats to THIM perturbs the balance between excitatory and inhibitory amino acids in the brain,shifting it toward excessive neuroexcitation. Despite of intrinsic limitations, present findings have important clinical implications, as they provide a plausible mechanism, whereby THIM exerts neurotoxic effects in the brain. It is likely that this mercurial—still present in pediatric vaccines in many countries—causes a similar disturbance of excitatory and inhibitory neurotransmitters in the brains of human infants, leading to neurotoxicity, encephalopathies, and in consequence to neurodevelopmental disorders, including autism.*

On the whole, the current study provides further empirical evidence that exposure to THIM leads to neurotoxic changes in the developing brain, arguing for urgent and permanent removal of this preservative from all vaccines for children (and adults) since effective, less toxic and less costly alternatives are available. The stubborn insistence of some vaccine manufacturers and health agencies on continuation of use of this proven neurotoxin in vaccines is testimony of their disregard for both the health of young generations and for the environment.”


 “In 2009, the US Dept. of Health and Human Services (HHS) charged the Institute of Medicine (IOM) with providing a thorough review of the current medical and scientific evidence on vaccines and vaccine adverse events. The IOM has concluded in its 2011 report that “Adverse events on our list thought to be due to IgE-mediated hypersensitivity reactions Antigens in the vaccines that the committee is charged with reviewing do not typically elicit an immediate hypersensitivity reaction (e.g., hepatitis B surface antigen, toxoids, gelatin, ovalbumin, casamino acids). However, as will be discussed in subsequent chapters, the above-mentioned antigens do occasionally induce IgE-mediated sensitization in some individuals and subsequent hypersensitivity reactions, including anaphylaxis” [11].

Ovalbumin would of course result in sensitization to egg. Casamino acid is derived from milk proteins and results in allergy to dairy.

Allergens contained in vaccines

Vaccines and injections contain food proteins such as chicken egg, casein, gelatin, soy, agar etc. [12]. They also contain ingredients such as Polysorbate 80 and sorbitol which are manufactured using food sources. Checking with a few suppliers, Polysorbate 80 is sourced from various food items such as coconut, palm, sunflower, tapioca, wheat, corn etc. Other vendors could be using other vegetable oils, legume oils and nut oils as the source for oleic acid used in the manufacture of Polysorbate 80. It is impossible to guarantee that these products do not contain residual allergen proteins from these food sources. No specification to limit allergen content in vaccines I was able to confirm with the Food and Drug Administration (FDA), the United States Pharmacopeia (USP) and vaccine maker Sanofi Pasteur that there are no specifications limiting allergen content in vaccines approved for use in the United States. In other words, no safe level has been established or enforced for allergens contained in vaccines. Vaccine excipient makers such as sorbitol, Polysorbate 80 manufacturers also have no limits on residual allergens in their injectable grade products. Since there are no limits, suppliers do not test for allergens in production. Further, residual allergens that may be present in the excipients are not even listed in the vaccine package inserts. O’Brien et al. [13] measured 7.4 mcg/ml of ovalbumin in influenza vaccines in 1967. Goldis et al. [14] measured as much as 38.3 mcg/ml in influenza vaccines as recently as 2008. The above observations are an obvious consequence of the lack of specifications or regulation of allergen content in vaccines.

Effect of adjuvants and multiple simultaneous vaccinations

Pertussis toxin and aluminum compounds act as adjuvants. These adjuvants are known to bias for IgE synthesis [15]. Injecting food proteins along with these adjuvants increases the immunogenicity of the food proteins that are present in the vaccines. With up to five shots administered simultaneously, numerous food proteins and adjuvants get injected at one time. This increases the probability of sensitization. Atsuko et al. [15] not only accepted that vaccine antigens and vaccine components induced allergies, they also acknowledge the role of aluminum in IgE synthesis. Hence they worked on an alternative to aluminum based adjuvants.”

http://www.omicsgroup.org/journals/evidence-that-food- proteins-in-vaccines-cause-the-development-of-foodallergies-and-its-implications-for- vaccine-policy-2329-6631-1000137.php?aid=60994

Atsuko et al. not only accepted that vaccine antigens and vaccine components induced allergies, they also acknowledge the role of aluminum in IgE synthesis. Hence they worked on an alternative to aluminum based adjuvants.


A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids

The number of patients with allergic reactions after administration of gelatin-containing live vaccines is increasingly reported in Japan. These allergic reactions appear to be caused by gelatin allergy…….In 206 patients from whom serum was available, IgE antibodies to gelatin were detected in 25 of 27 (93%) with anaphylaxis, 27 of 48 (56%) with urticaria, and 8 of 90 (9%) with a generalized eruption…… Among 202 patients for whom prior vaccine information was available, all had received DTaP vaccines…… CONCLUSION:  Most anaphylactic reactions and some urticarial reactions to gelatin-containing measles, mumps, and rubella monovalent vaccines are associated with IgE-mediated gelatin allergy. DTaP immunization histories suggest that the gelatin-containing DTaP vaccine may have a causal relationship to the development of this gelatin allergy.


Undiagnosed food allergies have been proposed as possible causes of promoting and perpetuating irritable bowel syndrome . Our aim was to find out if sensitization could induce chronic functional motor disturbances in the intestine and the mechanisms implicated. Rats were sensitized to ovalbumin (OVA) following three hypersensitivity induction protocols, two parenteral (injections) and one oral. All sensitized rats showed intestinal hypermotility. Only rats sensitized by parenteral procedure showed an increase in RMCP II after OVA challenge in serum. IgEs increased only in the Bordetella pertussis sensitized group.  All sensitized rats showed an increase in the number of mucosal mast cells in duodenum. In conclusion, hypersensitivity to food proteins induces chronic motor alteration that persists long after antigen challenge and an excited/activated state of sensitized mucosal mast cells.



The mean age of 93 patients was 26.5 ± 15 years; 69.2% were female and 21% were considered autoimmune susceptible. The mean (average) latency period from the last dose of hepatitis-B vaccine and onset of symptoms was 43.2 days. Of note, 47% of patients continued with the immunization program despite experiencing adverse events. Manifestations that were commonly reported included neuro-psychiatric (70%), fatigue (42%) mucocutaneous (30%), musculoskeletal (59%) and gastrointestinal (50%) complaints. Elevated titers of autoantibodies were documented in 80% of sera tested. In this cohort 80/93 patients (86%), comprising 57/59 (96%) adults and 23/34 (68%) children, fulfilled the required criteria for Autoimmune Syndrome induced by Adjuvants.


Common clinical characteristics were observed among 93 patients diagnosed with immune-mediated conditions post-hepatitis-B vaccine, suggesting a common denominator in these diseases. In addition, risk factors such as history of autoimmune diseases and the appearance of adverse event(s) during immunization may serve to predict the risk of post-immunization diseases. The “Autoimmune Syndrome induced by Adjuvants” criteria were found to be very useful among adults with post-vaccination events. The application of the “Autoimmune Syndrome induced by Adjuvants” criteria to pediatric populations requires further study.” Lupus. 2012 Feb


“The inactivated vaccine database restriction resulted in a 41 % reduction in background VAERS reports and a 24 % reduction in foreground VAERS reports.


Empirical Bayesian data mining in VAERS prospectively detected the safety signal for febrile seizures after Fluzone(®) 2010-2011 in young children. The EB05 threshold, database restrictions, adjustment and baseline data mining were strategies adopted a priori to enhance the specificity of the 2010-2011 influenza vaccine data mining analyses. A database restriction used to separate live vaccines resulted in a reduced EB05. Adjustment of data mining analyses had a larger effect on estimates of disproportionality than the MGPS algorithm. Masking did not appear to influence our findings. This case study illustrates the value of VAERS data mining for vaccine safety monitoring.” Drug Saf. 2013 Jul


(DoD employees are frequently vaccinated)
“We noted a higher proportion of Guillain-Barré syndrome (GBS) and cardiovascular reports in the Department of Defense (DoD) population compared to the civilian population. Data mining detected disproportional reporting of ataxia ((lack of muscle control during voluntary movements, such as walking or picking up objects)); clinical review revealed that ataxia was a component of diverse clinical entities including GBS.


Review of VAERS reports are reassuring, the only unexpected safety concern for LAIV3 identified was a higher than expected number of GBS reports in the DoD population, which is being investigated.” Vaccine. 2014 Nov



Acute respiratory failure with diffuse pulmonary opacities {{Lung, White spots, not transparent on X ray}}  is an unusual manifestation following influenza vaccination. We report herein a patient with chronic obstructive pulmonary disease who developed fever with worsening of respiratory symptoms and severe hypoxemia {{Low blood oxygen}} requiring ventilatory supportshortly after influenza vaccination.” 2014


“No safety comparisons could be carried out, emphasising the need for standardisation of methods and presentation of vaccine safety data in future studies. In specific cases, influenza vaccines were associated with serious harms such as narcolepsy and febrile convulsions. It was surprising to find only one study of inactivated vaccine in children under two years, given current recommendations to vaccinate healthy children from six months of age in the USA, Canada, parts of Europe and Australia. If immunisation in children is to be recommended as a public health policy, large-scale studies assessing important outcomes, and directly comparing vaccine types are urgently required. The degree of scrutiny needed to identify all global cases of potential harms is beyond the resources of this review. This review includes trials funded by industry.”

Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines. The review showed that reliable evidence on influenza vaccines is thin …. there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies.” 2012


Serotype replacement:


In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.

CONCLUSIONS: Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada.”


“Over the following 9 months, TIV (vaccine) recipients had an increased risk of virologically-confirmed non-influenza infections….

“There was no statistically significant difference in the risk of confirmed seasonal influenza infection between recipients of TIV (vaccine) or placebo, although the point estimate was consistent with protection in TIV recipient… TIV recipients had significantly lower risk of seasonal influenza infection based onserologic evidence…However, participants who received TIV (vaccine) had higher risk of Acute Respiratory Infections associated with confirmed noninfluenza respiratory virus infection. Including 2 additional confirmed infections when participants did not report ARI, TIV (vaccine) recipients had higher risk of confirmed noninfluenza respiratory virus infection. The majority of the noninfluenza respiratory virus detections were rhinoviruses and coxsackie/echoviruses, and the increased risk among TIV recipients was alsostatistically significant for these viruses….” 2012


Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.


Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to explain reduced protection. During the 2012-13 season, however, detailed genotypic and phenotypic characterization shows that low vaccine effectiveness was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic drift in circulating viruses.

The egg-adapted strain was itself antigenically distinct from the WHO-recommended prototype, and bore three AA mutations at antigenic sites B [H156Q, G186V] and D [S219Y]. Conversely, circulating viruses were identical to the WHO-recommended prototype at these positions with other genetic variation that did not affect antigenicity.

These findings underscore the need to monitor vaccine viruses as well as circulating strains to explain vaccine performance. Evolutionary drift in circulating viruses cannot be regulated, but influential mutations introduced as part of egg-based vaccine production may be amenable to improvements. {ya think?!}



Impact of Repeated Vaccination on Vaccine Effectiveness Against Influenza A(H3N2) and B During 8 Seasons

“In the analysis using 5 years of historical vaccination data, current season VE against H3N2 was significantly higher among vaccinated individuals with no prior vaccination history compared with vaccinated individuals with a frequent vaccination history…….
vaccine-induced protection was greatest for individuals not vaccinated during the prior 5 years. Additional studies are needed to understand the long-term effects of annual vaccination” NOV 2014

{Since children and infants receive 26 doses by the first year of life I assume they wouldnt get protection}

“the analysis using 5 years of historical vaccination data suggested a significant difference in current-season vaccine effectiveness among frequent vaccinees compared with nonvaccinees. Interference due to repeated prior vaccination is one possible explanation for this difference, but unmeasured confounding could also account for the observed differences. The potential immunologic mechanisms for vaccine interference are not well understood. Contributing factors may include “original antigenic sin,” immune exhaustion, and/or antigenic drift of circulating influenza viruses with respect to vaccine antigens….
The evidence of original antigenic sin is strongest for sequential natural influenza infections. It is unclear whether repeated influenza vaccination generates effects of similar magnitude.”


Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

“Receipt of TIV could increase influenza immunity at the expense of reduced immunity to noninfluenza respiratory viruses, by some unknown biological mechanism…..Participants who received TIV would have been protected against influenza in February 2009 but then would not have had heightened nonspecific immunity in the following weeks. They would then face a higher risk of certain other virus infections in March 2009, compared with placebo recipients (Figure 1). The duration of any temporary nonspecific immunity remains uncertain but could be of the order of 2–4 weeks based on these observations.” 2012


Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness

“Influenza-vaccinated children were 1·6 times more likely than unvaccinated children to have a non-influenza influenza like illness……
Non-influenza Influenza Like Ilnesses were more common among fully vaccinated and partially vaccinated subjects than among unvaccinated subjects …Excluding Influenza Like Ilnesses from which no virus was identified made no significant difference to this finding.” 2014


Epidemic of complicated mumps in previously vaccinated young adults in the South-West of France.

Five cases of meningitis, 1 of orchitis, and 1 of unilateral hearing impairment were identified. Each of the 7 patients had been previously vaccinated with MMR, 4 had received 2 doses of this vaccine. Blood tests revealed high rates of IgG antibodies, usually considered as sufficient for immunological protection, and every patient had at least 1 positive RT-PCR test for mumps.

Outbreaks of complicated mumps may still occur despite a broad coverage of MMR vaccination. The clinical presentation suggested mumps but the final diagnosis could only be confirmed by genomic detection of the virus. Unusual viral strains with increased neurovirulence”
{(increased capability of causing disease to the nervous system)}

” , insufficient population coverage associated with immunity decrease over time may explain outbreaks of COMPLICATED mumps.”

{{So even though the vaccines created “High rates of antibodies” the vaccine was STILL INEFFECTIVE.  Since 2 doses worked but didn’t work, adding another should do the trick. All risk, no benefit.}}

Med Mal Infect. 2014 Oct 25


“A Lot Must be Done to Understand How, in Certain Individuals, Alum-Containing Vaccines may Become Insidiously Unsafe”

Alum has been used for decades to levels considered as an acceptable compromise between its role of adjuvant and its toxic effects by the industry and the regulatory agencies. However, the MMF story revealed several gaps in the knowledge on alum particles, including their exact mechanisms of action, their fate after injection, their systemic dissemination, and their safety on the long-term. Efforts have been done in the last years to develop novel adjuvants, but attempts to seriously examine safety concerns raised by the bio-persistent character and brain accumulation of alum particles have not been made.” Front Neurol. 2015


Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity. The understanding of basic mechanisms of particle biopersistence and brain translocation represents a major health challenge, since it could help to define susceptibility factors to develop CHRONIC NEUROTOXIC DAMAGE….

In spite of their long usage, the literature has pointed out that the adjuvanticity mechanisms of aluminum salts remain basically UNKNOWN despite most active investigation in the field in recent years (21, 22). Alum is DEFICIENT AT INITIATING CELL-MEDIATED IMMUNITY and SKEWS THE IMMUNE RESPONSE toward a T-helper type 2 (Th2) response associated with strong production of IL-4 and the IgG1 antibody subtype….

Aluminum has long been identified as a neurotoxic metal, affecting memory, cognition and psychomotor control, altering neurotransmission and synaptic activity, damaging the blood–brain barrier (BBB), exerting pro-oxidant effects, activating microglia and neuroinflammation, depressing the cerebral glucose metabolism and mitochondrial functions, interfering with transcriptional activity, and promoting beta-amyloid and neurofilament aggregation (56). In addition, alum particles impact the immune system through their adjuvant effect and by many other means. They adsorb vaccine antigens on their surface, which protect them from proteolysis thus forming a persistently immunogenic pseudo-pathogen (57). Alum particles may also bind undesirable residual products inherent to vaccine production procedures, as shown for HPV DNA sequences (58) or yeast proteins (59) that may be potentially hazardous (60). Finally, alum particles can directly induce allergy (61, 62) as other metals (63).”Front Neurol. 2015


Our previous ecological studies of autism spectrum disorder (ASD) has demonstrated a correlation between increasing ASD rates and aluminium (Al) adjuvants in common use in paediatric vaccines in several Western countries. The correlation between ASD rate and Al adjuvant amounts appears to be dose-dependent and satisfies 8 of 9 Hill criteria for causality.

Repetitive administration of aluminium to neonatal mice in amounts comparable to those to children receive via routine vaccinations significantly increases anxiety and reduces exploratory behaviour and locomotor activities. The neurodisruptive effects of aluminium are long-lasting and persist for 6 months following injection.



Behavioral testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured by the wire-mesh hang test (final deficit at 24 wk; about 50%). Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group (4.3 errors per trial) compared with the controls (0.2 errors per trial) after 20 wk. Apoptotic neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord. The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants.


We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer’s and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.” 2013


The vaccination-stimulated Th2 pathway responsible for the production of antibodies, the pathway which predominates in neonates and infants, in the absence of an adequate balance of Th1 response may lead to the development of allergic reactions [25]. This is symptomatic of the fact that allergic diseases are often referred to as “an epidemic of the XXI century” [26, 27]. As stated in the “European Allergy White Paper”, the clinical symptoms of allergy are present in 35% of the population of developed countries, and according to the ISAAC (The International Study of Asthma and Allergies in Childhood) as many as 40%. Allergy is one of the major health problems on par with AIDS, cancer, cardiovascular diseases, injuries and accidents [28 – 30].

According to other authors, a restriction of the natural environmental infections stimulating Th1 response as well as change of their natural course resulting from mass immunization, an increase in general hygiene and widespread use of antibiotics (“Hygiene Theory”) inhibiting and delaying the adjustment of Th2/Th1 could theoretically also contribute to the growth of the risk of allergic diseases [31, 32]. A confirmation of this thesis was the study of Swiss children from anthroposoic backgrounds, in which significantly less atopy was observed than in children from other backgrounds. In this group, a positive correlation of diseases with the MMR vaccination was found [33].  In addition, in a series of papers, Silverberg et al. have shown that wild type varicella zoster virus infection (WTVZV), but not varicella vaccine (VV), protects against asthma and atopic dermatitis (AD) in young children [34, 35]. The protective effect of Wild Type Varicella Zoster Virus  was attributed to its beneficial effect on stimulating Th1-primed immune responses and suppressing allergy-promoting Th2 responses. According to Silverberg et al. [34], ―The introduction of widespread varicella vaccination and resultant decline of   Wild Type Varicella Zoster Virus in the United States may be a contributing factor in the increased prevalence of AD [atopic dermatitis] over the past few decades.‖ Notably, other than not providing an effective stimulus for proper immune system development, recent research has shown that vaccines are actually capable of disrupting it. For example, annual vaccination against influenza has been shown to hamper the development of virus- specific CD8+T-cell immunity in children [36]  From the above observations it is clear that the proper functioning of the immune system involves a delicate balance between the two arms of the immune equilibrium (Th1/Th2), and its tilt to either side can be harmful for the body [30]. Furthermore, it appears that the necessary Th1/Th2 balance is better provided by natural challenges (i.e., in a form of relatively benign childhood diseases such as chickenpox and mumps) rather than vaccination. Recent research by Singh of the Interna- tional Institute for Brain Research in the USA confirm the veracity of this statement. In the study, serum and cerebrospinal fluid (CSF) were analyzed in terms of viral and autoimmune markers in patients with autism compared with a group of healthy children – both groups were vaccinated with MMR (measles, mumps, rubella vaccine) [37].  This is the first of this type of research examining a positive correlation between viral factors (viral serology) and autoimmune factors (brain autoantibodies). It was found that higher levels of measles antibodies were accompanied by Myelin Basic Protein (MBP) autoantibodies in children with autism (Figure.3). A similar serology was found in CSF.

Download to Full Study:

The purpose of this study was to examine the role of pertussis toxin (PT) in inducing intestinal hypersensitivity reactions, particularly the ability of the adjuvant to prolong the sensitization…..

“Mice injected with pertussis and egg protein resulted in egg allergy.”[4]

CONCLUSIONS: Our findings indicate nanogram quantities of Pertussis Toxin, when administered with a food protein, result in long-term sensitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens.


“The immune-mediated reactions caused by individual components of the vaccines are outlined in Table 2. Allergic responses caused by vaccines are generally of Type I and IV hypersensitivity reactions.” Almost all the vaccine components can be considered as potential triggers of an allergic reaction. Of particular importance are culture derived proteins from egg, gelatin and yeast. Other sources of allergic reaction are antibiotics and vaccination antigens.”  Clin Exp Vaccine Res.


Aluminum-induced entropy in biological systems: implications for neurological disease.

“Over the last 200 years, mining, smelting, and refining of aluminum (Al) in various forms have increasingly exposed living species to this naturally abundant metal. Because of its prevalence in the earth’s crust, prior to its recent uses it was regarded as inert and therefore harmless. However, Al is invariably toxic to living systems and has no known beneficial role in any biological systems. Humans are increasingly exposed to Al from food, water, medicinals, vaccines, and cosmetics, as well as from industrial occupational exposure. Al disrupts biological self-ordering, energy transduction, and signaling systems, thus increasing biosemiotic entropy. Beginning with the biophysics of water, disruption progresses through the macromolecules that are crucial to living processes (DNAs, RNAs, proteoglycans, and proteins). It injures cells, circuits, and subsystems and can cause catastrophic failures ending in death. Al forms toxic complexes with other elements, such as fluorine, and interacts negatively with mercury, lead, and glyphosate. Al negatively impacts the central nervous system in all species that have been studied, including humans. Because of the global impacts of Al on water dynamics and biosemiotic systems, CNS disorders in humans are sensitive indicators of the Al toxicants to which we are being exposed.

In this paper, we will show that Al is harmful to the CNS, acting in a number of deleterious ways and across multiple levels, to induce biosemiotic entropy [17]. A countervailing view exists [18–20], but the assertions of safety are invariably based on weak epidemiological designs, ones that overwhelm significant negative signals with irrelevant noise factors. Such studies that fail to detect significant negative outcomes neither stand up to rigorous scrutiny nor outweigh better designed research, in a vast and growing literature, showing significant negative impacts sustaining the central hypothesis of this paper. Irrefutable research evidence shows that Al exposure is harmful. Further, results discussed in this paper show that it is counterfactual for researchers to argue that Al is universally safe or beneficial even in trace amounts.” J Toxicol. 2014


“Among the CNS problems in humans attributed to Aluminum are dialysis associated encephalopathy (DAE) [32, 62], autism spectrum disorders [9, 63, 64], Alzheimer’s disease, Parkinson’s disease, and related dementias [28, 36] including those typical in Down syndrome [18]. Experimental and clinical data show the CNS as the most sensitive organ system negatively impacted by Aluminum. Toxic effects manifest in impaired psychomotor control, altered behavior (i.e., confusion, anxiety, repetitive behaviors, sleep disturbances, deficits of speech, concentration, learning, and memory), and in potentially fatal seizures [18, 28, 38]. Aluminum has been identified as the efficient cause of a whole class of immune dysfunctions directly involving the CNS and known as “autoimmune-inflammatory syndrome induced by adjuvants” (ASIA) [65–68]. As will be seen in this paper, the disorders with which Aluminum has been associated as a causal factor are pervasive because they begin with the disruption of fluid structures involving water. Also, although Aluminum negatively affects every layer of the body’s biosemiotic systems, on which health depends, the symptoms of Aluminum poisoning are often noticed when they inevitably reach and impact the CNS.

1.2. The Toxic Effects of Aluminum as a Vaccine Adjuvant

Al salts (hydroxide and phosphate) are the most commonly used vaccine adjuvants and, until recently, the only adjuvants licensed for use in the USA [79–89]. In the absence of Al, according to their manufacturers, antigenic components of most vaccines (with the exception of live attenuated vaccines) fail to elicit the desired level of immune response [66, 80]. Although Al is neurotoxic, it is claimed by proponents that the concentrations at which Al is used in the vaccines do not represent a health hazard [19]. For that reason,vaccine trials often treat an Al adjuvant-containing injection as a harmless “placebo” (a comparison benchmark or control treatment) or they use another Al-containing vaccine to treat a “control group,” despite evidence that Al in vaccine-relevant exposures is universally toxic to humans and animals [9, 90, 91]. Its use in a supposed “placebo” or in any “control” treatment in vaccine trials is indefensible [95]. It is precisely analogous to comparing fire A against fire B, to make the argument that since A is no hotter than B, A is therefore not a fire.

During the last decade, studies on animal models and humans have shown that Al adjuvants by themselves cause autoimmune and inflammatory conditions [19, 79–81, 90, 95–103]. The animal models show that subcutaneous injections of Al hydroxide induced apoptotic neuronal death and decreased motor function in mice [2, 37–39] and sheep [43]. In newborn mice they were associated with weight increases, behavioral changes, and increased anxiety [2]. All these findings plausibly implicate Al adjuvants in pediatric vaccines as causal factors contributing to increased rates of autism spectrum disorders in countries where multiple doses are almost universally administered [9]. Also, as shown by Goldman and Miller in studies published in 2011 and 2012, strong correlations between infant mortality rates and the number of doses of vaccines administered also suggest deleterious impact of multiple exposures to their components [104, 105].

Follow-up experiments focusing on Al adjuvants in mice by Khan et al. [106] have shown that the adjuvants do not stay localized in the muscle tissue upon intramuscular injection. The particles can travel to the spleen and brain where they can be detected up to a year after the injection. Such findings refute the notion that adjuvant nanoparticles remain localized and act through a “depot effect.” On the contrary, the Al from vaccine adjuvants does cross the blood-brain and blood-cerebrospinal fluid barriers and incites deleterious immunoinflammatory responses in neural tissues [1–3, 9]. Tracking experiments in mice reveal that some Al hydroxide nanoparticles escape the injected muscle inside immune system cells such as macrophages, which travel to regional draining lymph nodes, where it can exit to the bloodstream gaining access to all organ systems, including the brain. As Khan et al. [106] have warned, repeated doses of Al hydroxide are “insidiously unsafe,” especially in closely spaced challenges presented to an infant or a person with damaged or immature blood brain or cerebrospinal fluid barriers [2]. Given macrophages acting as highly mobile “Trojan horses” [107], the Khan et al. warning suggests that cumulative Al from repeated doses in vaccines can produce the cognitive deficits associated with long-term encephalopathies and degenerative dementias in humans [40, 99].

The latest research by Luján et al. [43] described a severe neurodegenerative syndrome in commercial sheep linked to the repetitive inoculation of Al-containing vaccines. In particular, the “sheep adjuvant syndrome” mimics in many aspects human neurological diseases linked to Al adjuvants. Moreover, the outcomes in sheep were first identified following a mass-vaccination campaign against blue tongue and have now been successfully reproduced under experimental conditions following administration of Al-containing vaccines. Notably, the adverse chronic phase of this syndrome affects 50–70% of the treated flocks and up to 100% of the animals within a given flock. The disorder is made worse by cold weather conditions, suggesting synergy with other stress producing factors. The disorder is characterized by severe neurobehavioral outcomes—restlessness, compulsive wool biting, generalized weakness, muscle tremors, loss of response to stimuli, ataxia, tetraplegia, stupor, inflammatory lesions in the brain and the presence of Al in the CNS tissues, coma, and death [43]. These findings confirm and extend those of Khan et al. [106] who demonstrated the ability of Al adjuvants to cross the BBB, and they show that Al in the brain can trigger severe long-term neurological damage. The findings by Luján et al. [43] and Khan et al. [106] also show how and why reported adverse reactions following vaccinations are most commonly neurological and neuropsychiatric [6, 7].” J Toxicol. 2014



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